Subtypes of Fabry disease and their presentation

Complete absence of, or less than 1% of normal levels of, GAL A enzyme results in the “classic” sub-type of Fabry disease. Classic Fabry disease typically has an early onset, which can occur in childhood or adolescence.
Commonly, the earliest signs and symptoms of classic Fabry disease can include:

Classic Fabry Disease

Episodic excruciating pain and burning sensations in the hands and feet which are often provoked by physical exercise, fatigue, fever, stress, heat exposure, or change in weather conditions; such episodes are called Fabry crisis, and may persist for hours or days; pain may also be present in the arms or legs;
Sharp pain which can occur anywhere in the body;
Gastrointestinal problems, including abdominal pain and cramping, diarrhea, bloating, nausea, and inability to gain weight;
Raised or fat, dark-red, purplish or blue-black benign skin papules (angiokeratomas), the majority of which occur between the umbilicus and the knees;
Inability to perspire adequately or to perspire at all (anhydrosis), which results in overheating during physical activity, with resulting discomfort and fevers;
Corneal clouding (corneal dystrophy) that does not affect vision; and
Delayed puberty or delayed growth.

Late Onset Fabry Disease

Affected individuals whose GAL A enzyme is present at greater than 1% of normal levels have the more-or-less attenuated, later-onset sub-type of Fabry disease. They usually do not experience the classic sub-type early symptoms listed above. Rather, symptoms of kidney, heart or cerebrovascular involvement usually occur between the ages of 30 to 45. It is the first appearance of such kidney, heart or cerebrovascular symptoms that often leads to the initial diagnosis of late-onset Fabry disease. Males and affected females with late-onset Fabry disease may experience any of the following symptoms or complications.

NOTE: Individuals with the classic sub-type of Fabry disease may also add any of the following symptoms or complications to their early symptoms noted above as they age.

Severe kidney problems resulting in renal insufficiency and ultimately, end-stage renal failure;
Myocardial ischemia and infarction;
Transient ischemic attacks;
Cardiac arrhythmia;
Left ventricular hypertrophy;
Hypertrophic cardiomyopathy;
Cardiac failure;
Mitral valve prolapse or insufficiency;
Lymphedema in the feet and legs;
Hearing loss which can be progressive, and possible sudden deafness;
Frequent bowel movements after eating;
Joint or back pain;
Tinnitus and/or vertigo;
Generalized weakness;
Nausea and/or vomiting;
Chronic bronchitis or shortness of breath

Source; Indications, Newsletter of the Lysosomal Disease Network, February 2014.

Further reading

Read this article that discusses how a mutation is classified as Classic or Late-Onset. It also talks about prevalence of both subtypes.